The objective of this study was to determine the association between weight loss and drug-induced hepatotoxicity DIH. A retrospective observational study of active tuberculosis TB patients consecutively admitted in a tertiary referral TB centre in the Netherlands was conducted. The outcome measure for DIH was defined as hepatotoxicity necessitating interruption of anti-TB drugs. Multivariate logistic regression analysis on interruption of anti-TB drugs was performed, with age, sex, nutritional status, TB disease severity, drug resistance, comorbidity including baseline liver function tests, anti-TB drug regimen, co-medication and addictions as independent risk factors. This study shows that weight loss during TB treatment was the most important risk factor for DIH necessitating interruption of anti-TB drugs. Causes of weight loss during TB treatment and the association between weight change and hepatotoxicity need further investigation. Abstract The objective of this study was to determine the association between weight loss and drug-induced hepatotoxicity DIH. Publication types Research Support, Non-U. Substances Antitubercular Agents.
Weight gain during tuberculosis treatment is an important marker of the restoration of health. Tuberculosis TB, in addition to causing symptoms such as coughing and fever, often results in significant weight loss and lack of appetite. This weight loss—also known as wasting—leads to malnutrition and subsequent impairment of the immune system, and puts the TB sufferer at a much higher risk of dying from the disease. Indeed, TB remains a top cause of death around the globe. A Baylor College of Medicine study of patients being treated for active TB at a Houston hospital looked at the results of treatment, specifically with regard to whether patients regained some or all of the weight they had initially lost. The researchers hoped to discern patterns of weight gain in the patients and whether certain characteristics of the disease could predict whether a patient would gain weight. Weight gain during disease treatment is an important marker of the restoration of health, according to researchers. It is viewed as an indicator of response to treatment patient goes from catabolic phase—where they have more tissue breakdown—to anabolic phase, during which protein breakdown decreases and synthesis predominates.
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|And in tuberculosis why weight occurs loss were not mistaken Excuse||TB Nutritional Assessment Because of the clear link between under nutrition and active TB, nutritional assessment and management are necessary parts of TB treatment and care for many people with TB. Worldwide, it is the second biggest killer when compared to other diseases caused by a single infectious agent. So TB and under nutrition can cause a vicious cycle of worsening disease and under nutrition. Examples of different population groups are adults above 18 years, children and adolescents 6 – 18, children under 5 years of age and pregnant women.|