If you are taking prescription or over-the-counter Allegra for allergies, you should be aware that these medications can interact with fruit juices such as apple juice, grapefruit juice, or orange juice. In fact, if you drink fruit juice or even fruit punch within an hour or two of taking your medicine, you may lose the effectiveness of the drug entirely. Let’s talk about why fruit juice can be a problem with Allegra, why this is, and what you can do to avoid the interaction if you enjoy fruit juice. Allegra fexofenadine, is a non-sedating antihistamine that is available over-the-counter OTC without a prescription. Since becoming available over the counter, as well as being approved for young children as young as six months, Allegra will likely become even more popular for people with allergy symptoms. For this reason, it is important for people to know that taking Allegra along with various fruit juices, especially orange and grapefruit juice, reduces the absorption of Allegra by more than one-third, therefore making the medicine less effective. Allegra depends on specialized receptors on cells that line the small intestine called organic anion transporting polypeptides or OATPs. OATP proteins help chemicals such as some medications cross the biological membranes that are otherwise impermeable to these drugs. Fruit juices, such as grapefruit juice, orange juice, and apple juice contain compounds that inhibit OATPs and therefore limit the absorption of Allegra in the body.
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