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Weight gain is a common side effect of prednisone. Prednisone can also cause a redistribution of fat to the face, back of the neck and the abdomen, although these changes vary from person to person. Generally speaking, the higher the dose and the longer the treatment, the greater the changes. Weight gain while taking prednisone is typically due to fluid retention and increased calorie intake because of increased appetite. In addition, those with lung disease have more difficulty maintaining physical activity. Fluid retention can be controlled by eating a diet low in sodium — no more than 2, mg a day — and higher in potassium. You can find a list of high-sodium foods to avoid in the General Guidelines for Healthy Eating. Prednisone increases appetite, resulting in increased calorie intake.