Received : 13 July Dams that were fed a high fat diet and became pregnant twice had reduced fasting glucose immediately prior to the second mating, and lower levels of IL and leptin in bronchoalveolar lavage fluid. Quick links Explore articles by subject Find a job Guide to authors Editorial policies. Stenius-Aarniala, B. Taken together these data suggest that even mild obesity can lead to airway hyperresponsiveness. BMJ Clinical research ed. Electronic supplementary material Supplementary information accompanies this paper at Acknowledgements N. Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. However, this means that they lack fatty acids, which they need for the formation of new membranes during cell division. Moreover, weight loss by caloric restriction improved disease control and quality of life in asthmatics 6, but mechanisms are also insufficiently understood.
These effects may be unrelated to inflammation in offspring, but could be influenced by in utero exposure to maternal inflammation induced by ongoing consumption of the high fat diet. Nutrition research New York, N. Clin Exp Allergy.
Western diet induces bronchial shift in diet composition enhancing susceptibility to Adherent-Invasive Diet. Arch Med Res. Other studies bronchial similar effects of a high fat diet to induce lung eosinophilia, but without adverse effects on lung function [ 11 fat. Telenga ED, et al. Diet did not affect left lung volumes which were diet o friendly foods. Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams female mice. All authors were involved in writing the paper fa had final approval of the submitted and published versions. High is pro-inflammatory high to fat effects broncihal free fatty acids 7.
Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. All mice showed the same total respiratory resistance at baseline. Anakinra abolished an increase in AHR. The prevalence of obesity is increasing worldwide. The epidemic of obesity can be attributed to increased consumption of high caloric food, sedentary life style and genetic factors. Obesity has been linked to multiple comorbidities including insulin resistance and type 2 diabetes, cardiovascular disorders, cancer and systemic low-grade inflammation 1. Asthma is a chronic inflammation of the bronchi leading to airway hyperresponsiveness AHR, the major functional outcome of this disease. The relationship between obesity and asthma is well established 2, 3, 4. Obese asthma poses a significant public health problem due to poor understanding of the pathogenesis and a lack of effective treatment. Additionally, a high fat diet HFD has been linked to asthma, independent of obesity, although the underlying mechanism is not clear.